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Aquaporin-4 antibodies and disease certainty

Hi everybody. I’m sorry for everybody’s challenges and suffering with NMO. I recently had a neurology screening test performed by a third party functional med lab (Vibrant). It detected moderate levels of Anti-Aquaporin-4 antigens. I don’t have any clinical issues with my nervous system. But I do experience (for about 6 months now) mild aching in my right eye and occasionally the left. It comes and goes but is never very intense pain. No visual impairments. I see great opto-neurologists in Missouri but thus far they have not considered it necessary to have me tested for antibodies thru Mayo Clinic )more accurate test). What I can’t get a fix on is whether just having the antibodies necessarily means you will get NMO. I see one article published in 2021 that found the AQP-4 antibodies do not necessarily drive disease pathogenesis. Does anybody have any thoughts they can share with me? Thanks so much!

  1. Hi, so in my experience I had a few blood tests and a spinal tap, MRI which showed inflammation and I was diagnosed with MS first but then they decided to do the test for AQP4 antibodies, and they were present and then I was diagnosed with NMOSD. Most of the time, if you have this antibody (according to my neuro) you have NMOSD.

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