Progression of NMO

Neuromyelitis optica spectrum disorder (NMOSD or NMO) is a rare inflammatory disease of the central nervous system (eye nerves, spinal cord, and brain). NMOSD is sometimes also called neuromyelitis optica or NMO.1

Patterns of NMO

There are 2 patterns of NMO, monophasic and relapsing. Doctors assume every person has relapsing NMO, even after a single attack.2

Monophasic NMO

  • About 5 to 10 percent of cases
  • A single attack that lasts 1 to 2 months
  • Affects men and women equally2

Relapsing NMO

  • Ninety to 95 percent of cases
  • Much more common in women than in men
  • Periodic flares with some time in between2

Progression

The chance of recurrence of disease activity after a first attack is greater than 90 percent. Attacks in NMO can be devastating. Outcomes vary widely among people, but the condition is still considered potentially devastating. Left untreated, early and severe disability is common.3,4

Demyelination and NMO attacks

Nerve fibers in your brain, spinal cord, and eye have a protective coating called myelin. Damage to this layer is called demyelination. Conditions like NMO are demyelinating because they damage this protective layer.5

When this layer is damaged, nerve signals can slow or stop. This leads to brain and nerve problems.5

How often do the attacks occur?

After the first attack, NMO follows an unpredictable path, and remission can vary. Attacks can last weeks to months. Symptoms may last off and on for years. They may also be temporary and can fully or partially resolve, most often after a course of treatment. However, this may not be the case for everyone. Reactions to treatment are highly unpredictable.2

When untreated, relapsing NMO relapses on average every 7 months. However, it can also relapse more or less often. Those who are on treatment may have a relapse about every 15 months.2,6

What do the attacks look like?

Generally, NMO symptoms begin suddenly. While symptoms may be temporary, each attack is damaging to the nerve fibers. Some people appear to recover fully after an attack, while others do not.2

Figure 1. NMO Target Areas

Human head and torso are shown with arrows pointing to the brain, spinal cord, and eyes.

Eyes

The optic nerve is a bundle of nerve fibers. It is the communication cable between your eyes and your brain. Optic neuritis occurs when inflammation damages the optic nerve.7

Symptoms of optic neuritis may include:2,7

  • Sudden eye pain or headache – Usually, this is made worse with eye movement.
  • Problems with vision or complete loss of vision – This is usually in 1 eye but can affect both eyes. It can include partial or complete blindness, problems seeing different colors, blurred or tunnel vision, or poor depth perception.

Spine and muscles

Transverse myelitis occurs when inflammation damages the spinal cord. It is defined by symptoms and signs of nerve problems in the motor (movement) and sensory (sensation) tracts of the spinal cord.8,9

Transverse myelitis can cause a variety of symptoms. The most common symptoms include:9

  • Arm and leg weakness
  • Pain in the lower back, down the arms or legs, or around the belly
  • Abnormal sensations, such as burning, stinging, or numbness
  • Bowel and bladder problems, including an urgent need to use the toilet, loss of bowel or bladder control (incontinence), or constipation

Brain stem

Some people with NMO may develop nerve damage in the brain. Vomiting, nausea, and hiccups that are hard to control (intractable) may occur if the brain stem is affected. This is known as area postrema syndrome (APS). Between 16 and 43 percent of people with NMO have this syndrome. Outcomes vary depending on the amount of damage to the brain.3

Will it get worse or better?

When faced with a diagnosis of NMO, you will likely want to know if the disease will get better or worse over time. NMO affects everyone differently. The unpredictable course of disease makes it hard to know what will happen over time. New damage to the brain, eyes, and spinal cord during attacks can make the symptoms of NMO worse over time. Within 5 years, half of those diagnosed with NMO require a wheelchair.10

Some factors can predict a worse outcome in NMO, including:3

  • The number of relapses within the first 2 years after symptoms begin
  • The severity of the first attack
  • Age at onset of disease
  • Other autoimmune diseases

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Written by: Katie Murphy │ Last reviewed: September 2021