3 years ago for me. It was when rituximab started giving me GI issues. It was so bad & with the NMO nerve pain, I started to wish the end would come. The simpliest thing got me through it though. There was a red cardinal outside my window that hung around for a week or more. It was so beautiful against the winter snow! It brightened my day & gave me back the strength & positivity I try to have every day....